• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.

Pediatric Interest Group

From the very beginning in 1989, the CCCTG has made it a priority to have pediatric representation within the group.

The first pediatric study formally undertaken was in 2000, after Jacques Lacroix, Jamie Hutchison and Haresh Kirpalani obtained a CIHR grant that launched what they named a “pediatric interest group” within the CCCTG. Two large RCTs were started after this meeting, the TRIPICU study, which addressed an important issue in transfusion medicine in PICU, and the HypHIT study, which studied the efficacy of hypothermia as a treatment measure of severe head trauma in children. Both RCTs were published in the NEJM. Of note among the other pediatric accomplishments of the CCCTG are the publications of several TRIPICU substudies (Gauvin, Willems, Rouette), studies assessing adrenal function in critically ill children (Menon) and the effect of vasopressin in pediatric vasodilatory shock (Choong), a trendsetting H1N1 adult-pediatric collaboration to describe the impact of the H1N1 pandemic (Jouvet-Fowler), and studies that assessed the impact of hypothermia after pediatric cardiopulmonary arrest and after head injury (Hutchison) as well as venous thrombo-embolism in critically ill children (Hutchison), helium-oxygen therapy in severe bronchiolitis (Lacroix) and the application of scoring systems at the bedside to predict clinically significant deterioration in hospitalized children (Parshuram).

The pediatric group has published over 15 articles for the CCCTG. At the present time, almost all Canadian university-affiliated pediatric critical care units are represented within the CCCTG. The strength of the pediatric group within the CCCTG lies not only with the talent of its pediatric investigators leading studies on important issues for critically ill children, but also the immense spirit of collaboration and support that exists within the pediatric nucleus. Consistently reliable support and collaboration from pediatric members such as Farrell, Joffe, Wensley, Gottesman and others have permitted the development and success of pediatric research.

Current endeavours of pediatric researchers within the CCCTG have spawned a new generation of research in a wide variety of areas that affect critically ill children including:
  • Pediatric early warning system score and evaluation of outcomes in hospitalized children (Parshuram), assessment of consent issues (Menon)
  • Determination of death practices (Dhanani), immobility and PICU-acquired weakness  as well as exercise and early rehabilitation (Choong), pediatric fluid and vasoactive infusion dependant shock (Menon)
  • Traumatic brain injury and development of a tool to classify CTs in the young (Guerguerian)
  • Optimization of non invasive ventilation (Emeriaud),
  • Development of a clinical decision support system in mechanical ventilation (Jouvet),
  • Procalcitonin use in pediatric infection control (Fontela),
  • Development and implementation of a multicentre pediatric crisis resource management curriculum (Gilfoyle) and ongoing pediatric transfusion studies (Tucci & Lacroix)
  • Research on traumatic brain injury and the role of molecular biomarkers in prognostic models (Hutchison)
In addition, Roxanne Ward, a PICU nurse coordinator, started the CCCTG Research Coordinators group and has been a driving force behind it since then. 

Link to Pediatric Documentation Centre (Members Only)