• Excellence

    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.

  • National

    The CCCTG is a national organization of more than 350 individuals with research interests in the management of the critically ill patient.

  • Clinical

    The CCCTG has more than 75 research programs underway and over 260 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.

  • Impact

    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous & ethical manner, and communicated in a timely & effective way to maximise impact.

  • Direction

    Leading Science, Saving Lives — 5-year Strategic Plan to further enhance the impact of the CCCTG in Canada and around the world.

  • Research

    The Canadian Critical Care Translational Biology Group (CCCTBG) is a collegial group that is dedicated to the pursuit of excellence and promotion of translational research related to critical care conditions.

  • Focus on
    New Publication

    The CCCTG congratulates member and Research Program Manager Marie-Hélène Masse on the publication of her MSc paper, “The evolution of mean arterial pressure in critically ill patients on vasopressors before and during a trial comparing a specific mean arterial pressure target to usual care.” Click Learn More to read the paper, published January 3 in BMC Anesthesiology.

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    Tom Stelfox awarded Distinguished Lecturer in Critical Care Sciences

    CCCTG congratulates Dr. Stelfox on this recognition from CIHR and Canadian Critical Care Society. The award recognizes an individual's outstanding contribution to the advancement of critical care sciences in Canada. Tom receives the award and gives a keynote lecture at Canadian Critical Care Forum (CCCF) taking place Dec 6 – 8th.

  • Focus on
    Call for Submissions

    Canadian Journal of Anesthesia: Special Issue on Equity in Anesthesiology and Critical Care in Canada

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    CCCTG submission to CIHR consultation on TCPS 2 guidance

    The Panel on Research Ethics and Secretariat for Responsible Conduct of Research recently proposed new guidance for multi-jurisdictional review by Research Ethics Boards. We are pleased by the proposed requirement for a single REB of record for low risk studies, and encourage moving toward a single ethics approval for all multi-jurisdictional studies. Read CCCTG's formal submission to the public consultation.

  • Focus on
    New Publication Oct. 4th in JAMA

    New findings published in Journal of Journal of the American Medical Assocation (JAMA) show that among critically ill adults with confirmed COVID-19, treatment with 2 units of high-titer, ABO-compatible convalescent plasma had a low likelihood of providing improvement in the number of organ support–free days.

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    New Publication in JAMA

    Randomized Clinical Trial results published September 2021 show that among critically ill patients requiring mechanical ventilation, administration of the probiotic L rhamnosus GG compared with placebo resulted in no significant difference in the development of ventilator-associated pneumonia.

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    New paper highlights the need for nationally coordinated data collection

    The paper proposes three solutions to create a “learning healthcare system” (1) create a process to easily add new fields to data that is collected on hospital discharges when needed (2) enable the national coordination of data and research and (3) create and support durable national research and quality improvement networks.

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    Therapeutic Anticoagulation in hospitalized COVID-19 patients

    ATTACC, ACTIV-4a and REMAP-CAP teams publish results in the New England Journal of Medicine from two RCTs addressing therapeutic anticoagulation in hospitalized COVID-19 patients.

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    CCCTG submission to Health Canada's regulatory modernization

    We are encouraged by the proposed direction in Health Canada's Clinical Trials Regulatory Modernization initiative. Click Learn More to read CCCTG's formal submission to the public consultation.

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    Ellen McDonald recognized with 2021 Deborah J. Cook Mentorship Award

    This year’s recipient of the Deborah J. Cook Mentorship Award is Ellen McDonald. Ellen has spent more than 25 years as a Research Coordinator for McMaster University, based at St. Joseph’s Healthcare Hamilton and Hamilton Health Sciences and has played a pivotal role in CCCTG. We congratulate Ellen on this significant achievement and thank her for her tremendous contribution to critical care research!

  • Focus on
    G7 Health Ministers Declaration

    Canada and other G7 Health Ministers endorse the G7 Therapeutics and Vaccines Clinical Trials Charter in their Oxford Declaration June 4, 2021. Includes commitment to “work with G7 regulators, ethics institutions and committees to achieve greater harmonisation and to streamline regulatory process to act more proportionately to risk.”

  • Focus on
    Brenda Lucas as Executive Director of the CCCTG

    The CCCTG Board is delighted to introduce Brenda Lucas as the next CCCTG Executive Director. Brenda has most recently been seconded to the University of Waterloo to help with resuming research activities during COVID, and prior to this as the executive director for the Ontario water consortium. Previously, she was senior policy advisor to two Ministers of Environment for Ontario.

  • Focus on
    How is invasive mechanical ventilation discontinued and do discontinuation practices differ internationally?

    Recently completed IOS observational study describe practice variation in IMV discontinuation internationally, associations between initial discontinuation events and outcomes, and factors associated with the use of select discontinuation strategies and failed initial spontaneous breathing trials (SBTs). The IOS study was published in JAMA.

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    How to define death?

    Recently completed DePPaRT study provides information about the process of death after withdrawal of life sustaining therapy in the ICU. The DePPaRT study was published in The New England Journal of Medicine.

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    Diversity in Critical Care Medicine is Important!

    Equity, diversity, and inclusion are core values of the CCCTG. Diversity in life experiences and backgrounds provide diversity of thought. Diversity of thought leads to the best science. It is important to represent the gender, cultural, and ethnic diversity of the critical care community to ensure representativeness, provide role models, and foster a critical care community based on inclusivity.  Click Learn More to read CCCTG's policy.

  • Focus on
    Research Chair in Pandemic Preparedness Research

    The Health Research Foundation (HRF) of Innovative Medicines Canada (IMC) announces that Dr. Srinivas Murthy has been awarded the Health Research Foundation of Innovative Medicines Canada Chair in Pandemic Preparedness Research.

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    Innovative adaptive trial design to evaluate multiple treatment options simultaneously

    REMAP-CAP uses a novel and innovative trial design able to adapt in the event of pandemics, and increases the likelihood that patients will receive the treatment that is most likely to be effective for them. REMAP-CAP is currently enrollling COVID-19 patients. Click on Learn More to get to the trial website.

  • Focus on
    Canadian Treatments for COVID-19

    In conjunction with the World Health Organization, Canada is participating in the SOLIDARITY trial, a global platform of research that is in various stages of approval in over 90 countries. 

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    The LOVIT Trial: Lessening Organ dysfunction with VITamin C

    Recent preliminary evidence suggests that intravenous vitamin C may be the first therapy to mitigate the dysregulated cascade of events transforming an infection into sepsis. However, definitive practice changing evidence requires a large trial powered to detect a plausible, modest, and clinically important difference in mortality. Click on Learn More to learn more about LOVIT.

  • Focus on
    Rapid research response to contribute to global efforts to contain the Coronavirus outbreak

    The CIHR supports Drs. Jeanna Parsons Leigh and Srinivas Murthy through the Canadian 2019 Novel Coronavirus (COVID-19) Rapid Research Funding Opportunity.

  • Focus on
    Gender differences in funding rates

    Study reveals gender disparity exists in grant and personnel award success rates, especially for grants directed to selected research communities. This information is important to address potential sources of bias in the review process. Click Learn More to read the full article.

  • Focus on
    Statement from CIHR supporting critical care research

    Dr. Brian Rowe acknowledges the role of research in critical care medicine and recognize the excellent work of health care professionals who provide intensive care. He also mentions contribution and impact of the CCCTG.

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    A global collaboration of acute care clinical researchers

    InFACT members include three dozen investigator-led research consortia from around the world. These groups have conducted many of the most impactful clinical trials in critical care. This year marks the 10th Anniversary of InFACT.

  • Focus on
    CCCTG launches new website for patients and families

    The CCCTG Patient and Family Engagement Committee has just launched the new website for patients and families who are experiencing, or have experienced, critical care. The purpose of the website is to support and engage patients and families in research.

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    The CCCTG awards two research fellowships

    The CCCTG is thrilled to support Drs. Nadia Roumeliotis and Oleksa Rewa so they can add to their experience by engaging in critical care research.  We are thankful to our partners, Fonds de recherche santé Québec and Alberta Health Services through the Critical Care Strategic Clinical Network for their contributions to the CCCTG Fellowship Program.

  • Focus on
    Following the patients and families after critical illness

    The RECOVER Program, lead by Dr. Margaret Herridge aims to elucidate the impact of critical illness and the caregiving situation on patients' and caregivers' long-term physical function and mental health.

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    Care in Canadian ICUs

    The CCCTG contributes to the development of the report from the Canadian Institute of Health Information (CIHI) about the care in Canadian intensive care units. Click Learn More to access CIHI's report.

  • Focus on
    Prediction of neurological outcomes following severe traumatic brain injury

    The TBI-Prognosis study aims at developing a prediction model to help provide objective information to patients and families on long-term prognosis in critically ill patients with severe traumatic brain injury. This multicenter prospective study is conducted by Dr Alexis Turgeon and a team of colleagues in 17 centers across Canada. Enrolment in the study has just been completed and 12-month follow-up outcome measures are ongoing.

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    Optimal use of vasopressors in patients suffering from vasodilatory shock

    François Lamontagne and the OVATION team have published the results from the pilot sutdy.  Click Learn More to view a video from Dr. Lamontagne and colleagues explaining the trial and the use of vasopressors in critically ill patients.

  • Focus on
    Renal replacement therapy in the critically ill – early the better?

    Acute kidney injury (AKI) is a common and increasingly encountered complication of critical illness. The STARRT-AKI research program aims to investigate strategies to starting acute renal replacement therapy in critically ill patients with severe AKI.

  • Focus on
    Value of investigator-led clinical trials

    Researchers from the CCCTG investigated factors influencing the impact of clinical trials.  Authors found that investigator-lead clinical trials increasingly shape the knowledge base of critical care, in particular trials led by investigators within structured critical care research consortia.  Click Learn More to read the full article.

  • Focus on
    The importance of Vitamin D in critically ill children

    Dr. Dayre McNally, physician in CHEO’s pediatric intensive care unit, investigates how optimizing Vitamin D levels can help treat critically ill children. Click Learn More to view Dr. McNally's video.

  • Focus on
    Can we better predict extubation outcomes?

    Prolonged mechanical ventilation and failed extubation harm patients. The WAVE score is able to predict extubation failures better than simple vitals, clinical impression and commonly used indices, in particular in patients perceived as high-risk.

  • Focus on
    Sedation management in the critically ill

    All critically ill, mechanically ventilated patients in the Intensive Care Unit receive medications to relieve pain and anxiety. However, accumulation of these medications can be associated with serious complications. Researchers from the CCCTG compared sedation strategies in critically ill mechanically ventilated patients.

  • Focus on
    Outcome and Research Priorities in Intensive Care Studies (OPTICS)

    The OPTICS research program lead by Drs. John Muscedere and François Lamontagne aims to understand differences in priorities between patients, citizens, decision-makers and researchers about research priorities and outcomes assessment in critical care clinical research.  Click on Learn More for a short video (in French only) presenting the OPTICS study.

  • Focus on
    Old blood as good as fresh blood in critically ill patients

    Blood used for transfusions is perishable. But contrary to general belief, results from a new study from CCCTG researchers published today in the New England Journal of Medicine shows that blood stored for three weeks is just as good as fresh blood.

  • Focus on
    Better treatment strategies for critically ill patients and the potential impact for the healthcare system

    The results of the PROTECT Trial and the recent corresponding cost-effectiveness study showed better health outcomes and overall, lower health care costs when using low molecular weight heparin dalteparin for the prevention of venous thromboembolism in the ICU.

  • CCCTG Meeting

    The CCCTG 2021 (fall - virtual) and 2022 (winter/spring) Scientific Meeting dates have been confirmed!

  • CCCRCG Grant

    The 2021 CCCRCG Research Grants have been awarded! Stay tuned for the 2022 competition.

  • CCCTBG Meeting

    The CCCTBG 2021/2022 Scientific Meeting dates have been confirmed!

  • Mentorship

    The Deborah J. Cook Mentorship Award 2021 has been awarded! Stay tuned for the 2022 call for nominations. 

  • Dr. Meade

    Dr. Maureen Meade - 2020 CIHR‑ICRH/CCCS Distinguished Lecturer Award in Critical Care Sciences

  • CCCTG Grant

    Request for applications for the CCCTG Early Career Research Grant 2020.  The submission deadline is September 21, 2020 at 5pm EDT.

  • Dr. Lacroix

    Dr. Jacques Lacroix – Recipient: 2019 CIHR‑ICRH/CCCS Distinguished Lecturer Award in Critical Care Sciences

  • 2018 Annual Report

    We are pleased to announce the CCCTG 2017-2018 Annual Activity Report is now available. Click Learn More to access it.

  • Dr. Cook

    Congratulations to Deborah Cook for being chosen a recipient of the 2018 CIHR Gold Leaf Award. 

  • Code of Conduct

    The CCCTG is adopting a Code of Conduct Policy.

  • Diversity Policy

    The CCCTG is adopting a policy to support diversity in its governance and sponsored activities.

  • Dr. Marshall

    Dr. John Marshall – Recipient: 2018 CIHR‑ICRH/CCCS Distinguished Lecturer Award in Critical Care Sciences

  • World Sepsis

    World Sepsis Day is on September 13, 2018.  Support this initiative led by the Global Sepsis Alliance.

  • Dr. Stelfox

    In recognition to his exceptional contributions to the promotion of critical care research through mentorship, Dr. Henry T. Stelfox receives the 2017 Deborah J. Cook Mentorship Award.

  • Dr. Turgeon

    Alexis Turgeon receives a Canada Research Chair in Critical Care Neurology and Trauma 

  • Dr. Pagliarello

    Dr. Giuseppe Pagliarello receives lifetime achievement award in organ donation from Trillium Gift of Life Network.

  • Dr. Menon

    Kusum Menon receives a Tier 2 Research Chair in Pediatric Shock from the University of Ottawa!