• Excellence

    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.

  • National

    The CCCTG is a national organization of more than 350 individuals with research interests in the management of the critically ill patient.

  • Research

    The CCCTG has more than 75 research programs underway and over 260 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.

  • Impact

    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous & ethical manner, and communicated in a timely & effective way to maximise impact.

  • Direction

    Leading Science, Saving Lives — 5-year Strategic Plan to further enhance the impact of the CCCTG in Canada and around the world.

  • Focus on
    CCCTBG & CCCTG Scientific Meetings - Winter 2018

    The Winter 2018 Scientific Meeting of the CCCTBG and CCCTG will be held at the Lake Louise Inn, Lake Louise AB.  The CCCTBG (January 21-22, 2018) and CCCTG (January 22-25, 2018) meetings are for members only. The online registration is now open, please follow this link to register your interest in attending the meeting. 

  • Focus on
    The CCCTG awards two research fellowships

    The CCCTG is thrilled to support Drs. Nadia Roumeliotis and Oleksa Rewa so they can add to their experience by engaging in critical care research.  We are thankful to our partners, Fonds de recherche santé Québec and Alberta Health Services through the Critical Care Strategic Clinical Network for their contributions to the CCCTG Fellowship Program.

  • Focus on
    Following the patients and families after critical illness

    The RECOVER Program, lead by Dr. Margaret Herridge aims to elucidate the impact of critical illness and the caregiving situation on patients' and caregivers' long-term physical function and mental health.

  • Focus on
    Care in Canadian ICUs

    The CCCTG contributes to the development of the report from the Canadian Institute of Health Information (CIHI) about the care in Canadian intensive care units. Click Learn More to access CIHI's report.

  • Focus on
    Prediction of neurological outcomes following severe traumatic brain injury

    The TBI-Prognosis study aims at developing a prediction model to help provide objective information to patients and families on long-term prognosis in critically ill patients with severe traumatic brain injury. This multicenter prospective study is conducted by Dr Alexis Turgeon and a team of colleagues in 17 centers across Canada. Enrolment in the study has just been completed and 12-month follow-up outcome measures are ongoing.

  • Focus on
    Optimal use of vasopressors in patients suffering from vasodilatory shock

    François Lamontagne and the OVATION team have published the results from the pilot sutdy.  Click Learn More to view a video from Dr. Lamontagne and colleagues explaining the trial and the use of vasopressors in critically ill patients.

  • Focus on
    Renal replacement therapy in the critically ill – early the better?

    Acute kidney injury (AKI) is a common and increasingly encountered complication of critical illness. The STARRT-AKI research program aims to investigate strategies to starting acute renal replacement therapy in critically ill patients with severe AKI.

  • Focus on
    Value of investigator-led clinical trials

    Researchers from the CCCTG investigated factors influencing the impact of clinical trials.  Authors found that investigator-lead clinical trials increasingly shape the knowledge base of critical care, in particular trials led by investigators within structured critical care research consortia.  Click Learn More to read the full article.

  • Focus on
    The importance of Vitamin D in critically ill children

    Dr. Dayre McNally, physician in CHEO’s pediatric intensive care unit, investigates how optimizing Vitamin D levels can help treat critically ill children. Click Learn More to view Dr. McNally's video.

  • Focus on
    Can we better predict extubation outcomes?

    Prolonged mechanical ventilation and failed extubation harm patients. The WAVE score is able to predict extubation failures better than simple vitals, clinical impression and commonly used indices, in particular in patients perceived as high-risk.

  • Focus on
    Sedation management in the critically ill

    All critically ill, mechanically ventilated patients in the Intensive Care Unit receive medications to relieve pain and anxiety. However, accumulation of these medications can be associated with serious complications. Researchers from the CCCTG compared sedation strategies in critically ill mechanically ventilated patients.

  • Focus on
    How to define death?

    Article in Critical Care Medicine showed that it is feasible and acceptable to study the natural history of death after withdrawal of life sustaining therapy in the ICU.  The DePPaRT study aims to aims to provide much needed information to provide guidance to "donation after circulatory death (DCD)" practice.

  • Focus on
    Outcome and Research Priorities in Intensive Care Studies (OPTICS)

    The OPTICS research program lead by Drs. John Muscedere and François Lamontagne aims to understand differences in priorities between patients, citizens, decision-makers and researchers about research priorities and outcomes assessment in critical care clinical research.  Click on Learn More for a short video (in French only) presenting the OPTICS study.

  • Focus on
    Old blood as good as fresh blood in critically ill patients

    Blood used for transfusions is perishable. But contrary to general belief, results from a new study from CCCTG researchers published today in the New England Journal of Medicine shows that blood stored for three weeks is just as good as fresh blood.

  • Focus on
    Better treatment strategies for critically ill patients and the potential impact for the healthcare system

    The results of the PROTECT Trial and the recent corresponding cost-effectiveness study showed better health outcomes and overall, lower health care costs when using low molecular weight heparin dalteparin for the prevention of venous thromboembolism in the ICU.

  • Dr. Rose

    In recognition to her exceptional contributions to the promotion of critical care research through mentorship, Dr. Louise Rose receives the 2018 Deborah J. Cook Mentorship Award.

  • CCCRCG Grant

    Request for applications for the CCCRCG Research Grant Competition 2018.  The submission deadline is Friday March 16, 2018 at 5pm EST.

  • CCCTG Retreat

    The CCCTG Young Investigators Retreat 2018. Application deadline is April 2, 2018

  • CCCTBG Meeting

    The CCCTBG Winter 2018 Scientific Meeting will be held in Lake Louise AB, January 21-22, 2018.

  • 2018 Meeting

    The CCCTG Spring 2018 Scientific Meeting will be held June 4-7, 2018 in Niagara on the Lake ON.

  • 2016 Annual Report

    We are pleased to announce the CCCTG 2016 Annual Activity Report is now available. Click Learn More to access it.

  • Dr. Cook

    Dr. Deborah Cook – Recipient: 2017 CIHR‑ICRH/CCCS Distinguished Lecturer Award in Critical Care Sciences

  • Dr. Turgeon

    Alexis Turgeon receives a Canada Research Chair in Critical Care Neurology and Trauma 

  • Dr. Pagliarello

    Dr. Giuseppe Pagliarello receives lifetime achievement award in organ donation from Trillium Gift of Life Network.

  • Dr. Hébert

    Paul Hébert receives the Research Chair Fondation Héma-Québec-Bayer in transfusion medicine from l'Université de Montréal.

  • Dr. Menon

    Kusum Menon receives a Tier 2 Research Chair in Pediatric Shock from the University of Ottawa!