• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.
Coordinates

Brent Winston

Dr. Brent W. Winston is an 
Associate Professor Departments of Critical Care Medicine, Medicine, and Biochemistry and Molecular Biology. 
Member: Immunology Research Group and Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School Of Medicine, University of Calgary, Calgary.

The research focus in my laboratory has been in three areas:
1) We are primarily interested in using metabolomics to study human diseases in Critical Care. We continue to study metabolomics in sepsis, lung injury (ARDS) and head injury (traumatic brain injury, TBI).
2) Gene regulation in sepsis.  We have examined gene regulation in macrophages in sepsis with a focus on the alternative complement cascade Factor B and have examined IGF-I gene regulation in lungs with an interest in acute and chronic lung fibroproliferation.
3) Clinical/Translational studies on sepsis. We have participated in a number of sepsis clinical studies.  To this end, I have created a Critical Care Tissue bank to conduct translational research on clinically important problems in the ICU and have also created a wet lab within the ICU to manage samples.
My laboratory is particularly interested in conducting translational research on clinically relevant Critical Care and Pulmonary disease processes.