Dr. Brent W. Winston is an
Associate Professor Departments of Critical Care Medicine, Medicine, and Biochemistry and Molecular Biology.
Member: Immunology Research Group and Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, Cumming School Of Medicine, University of Calgary, Calgary.
The research focus in my laboratory has been in three areas:
1) We are primarily interested in using metabolomics to study human diseases in Critical Care. We continue to study metabolomics in sepsis, lung injury (ARDS) and head injury (traumatic brain injury, TBI).
2) Gene regulation in sepsis. We have examined gene regulation in macrophages in sepsis with a focus on the alternative complement cascade Factor B and have examined IGF-I gene regulation in lungs with an interest in acute and chronic lung fibroproliferation.
3) Clinical/Translational studies on sepsis. We have participated in a number of sepsis clinical studies. To this end, I have created a Critical Care Tissue bank to conduct translational research on clinically important problems in the ICU and have also created a wet lab within the ICU to manage samples.
My laboratory is particularly interested in conducting translational research on clinically relevant Critical Care and Pulmonary disease processes.