• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.

Canadian Treatments for COVID-19

This national clinical trial plans to identify the optimal treatments for hospitalized patients with COVID19. It is an unprecedented opportunity for collaboration, in unprecedented times.
In conjunction with the World Health Organization, Canada is participating in the SOLIDARITY trial, a global platform of research that is in various stages of approval in over 90 countries. This trial, with a common control arm and shared randomization, will generate rapidly applicable data for patients around the world. New arms will be added as they emerge, and arms that demonstrate harm or futility will be removed through frequent interim analyses by a global DSMB.

In Canada, we are currently randomizing hospitalized patients with confirmed COVID19 to one of:
  • Optimized supportive care
  • Optimized supportive care + Remdesivir
  • Optimized supportive care + Lopinavir/ritonavir
  • Optimized supportive care + Hydroxychloroquine
The primary outcome is hospital mortality.
This simple trial is currently enrolling across Canada, and Canada is informing the global clinical trials response. Funding is through CIHR.
For more information, click here to email for a start-up package, including the protocol, case report forms, and start-up slides.