• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.

Rapid research response to contribute to global efforts to contain the Coronavirus outbreak

CONGRATULATIONS to Drs. Jeanna Parsons Leigh and Srinivas Murthy!

CIHR announces on March 6, 2020 that Nominated Principal Investigator Jeanna Parsons Leigh and Srinivas Murthy are recipients of a COVID19 Rapid Research Funding Opportunity.

As COVID-19 spreads globally, the World Health Organization, national governments, and health networks are working to keep the public informed with accurate and up-to-date information. However, the sharing of false information continues to have a negative impact on how people and communities are responding to the outbreak. Widespread fear, discrimination, and misuse of health services are just some examples of how misinformation has negatively impacted communities.  A better understanding of the social and cultural factors contributing to public knowledge and perceptions of COVID-19 are needed to support the development of evidence-informed strategies to combat misinformation, stigma and fear. Upon seeing the public reaction to COVID-19, Dr. Parsons Leigh recognized the unique opportunity to conduct a research study that centers on understanding public perceptions and associated implications of COVID-19 to develop strategies to close identified knowledge gaps. Dr. Parsons Leigh and her coleagues are working with members of the public, clinicians and researchers from across the country to combat misinformation, stigma and fear around COVID-19. The ultimate goal of this research project is to educate, engage and empower members of the public to be informed stewards of their health during the current and future infectious disease outbreaks.

Alongside a large team of investigators across the CCCTG and the Association of Medical Microbiology and Infectious Diseases (AMMI), Dr. Murthy will lead a series of studies will be performed of hospitalized patients of all ages with COVID19. First, building on the established SPRINT-SARI work, an observational study of infected patients will continue to better characterize this new disease. Second, a hospital-wide trial of antivirals in patients infected with COVID19 is being organized. This will provide the first evidence for treatment of infected patients, evaluating whether a commonly used anti-HIV medication can be repurposed for treating patients with COVID19, performed in conjunction with the World Health Organization as part of a global, coordinated effort to better understand how to best manage this new disease. In addition, REMAP-CAP will enroll the severely ill patients in participating sites in an adaptive platform trial evaluating a series of interventions, including antivirals, steroids, and immunomodulators, to determine what is the best strategy of care for severely ill patients with COVID19.