• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.


Programs ▼Principal Investigator(s)Coordinator(s)Status 
WAVE - A Multicenter Evaluation of Altered Heart Rate and Respiratory Rate Variability to Predict Extubation FailureAndrew SeelyAnna FazekasCompletedLearn More
VITdAL-PICU - Rapid normalization of vitamin D in critically ill childrenDayre McNallyKatie O’HearnCompletedLearn More
TOP UP - A Randomized Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill PatientsDaren Heyland
Rupinder Dhaliwal (Project Leader) and Maureen Dansereau (Project Assistant)EnrollingLearn More
THRRIVES - Temperature, Heart and Respiratory Rate Investigation along with Variability Evaluation and Serum Biomarkers StudyAndrew Seely, Christopher BredesonKaitlyn Chambers, Anna Fazekas
EnrollingLearn More
The REDOXS© Study  PublishedLearn More
The REALISTIC 80 Study  PublishedLearn More
The CANTREAT Study  PublishedLearn More
Teams 4 KidsElaine GilfoyleDeanna KootEnrollingLearn More
TBI-PrognosisAlexis TurgeonLucy Clayton and Caroline LégerCompletedLearn More
SuDDICU - Selective Decontamination of the Digestive Tract in the ICUBrian CuthbertsonTo be announcedNot Yet Recruiting Learn More
STRIPES — Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent ShockKusum MenonKatie O’HearnCompletedLearn More
STARRT-AKI – Standard vs. Accelerated Renal Replacement Therapy in Critically Ill Patients with Acute Kidney InjurySean Bagshaw, Ron WaldJanice Jansen-PereiraEnrollingLearn More
SPICE - Adverse drug reactions in the critically ill Yoanna Skrobik EnrollingLearn More
SLEAPSangeeta MehtaLisa BurryPublishedLearn More
SEVA - Improving Safety of Sedation Practice and Critical Illness PrognosticationAndrew SeelyAnna FazekasEnrollingLearn More
SENIOR Trial- Screening Elderly PatieNts For InclusiOn in a Weaning TrialKaren Burns

 CompletedLearn More
RELEASE TrialKaren Burns

Leena RizviCompletedLearn More
RECOVERMargaret Herridge

Program Manager: Priscila Robles

Research Coordinators: UHN (TWH)Andrea Matte, Paulina Farias, Cheryl Geen-Smith; MSH - Cheryl Ethier, Maedean Brown, Brittany Giacomino and Sumesh Shah; SMH - Orla Smith, Yoon Lee, Kerri Porretta, Julia Lee and Melissa Wang; SHSC - Nicole Marinoff, Jane Wang, Derek Parsotam and Ashwati Raghunath; SJH - Andrea Tkaczyk and France Clarke; OHSC - Mary-Jo Lewis, Tracey McArdle and Brigette Gomes; SPH - Lynda Lazosky, Ellen Woo; CHUS - Chantal Langevin, Karine Grondi, Joanie Lacasse-Bedard and Eugenie Pinsonnault; HMR: Joanne Harvey
EnrollingLearn More
PROSPECT — Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization TrialDeborah CookNicole Zytaruk et France ClarkeEnrollingLearn More
Plasma Transfusions in Critically Ill Children - Point Prevalence StudyOliver Karam To come.EnrollingLearn More
PIT-TBIFrançois LauzierLucy ClaytonEnrollingLearn More
OVATION — Optimal VAsopressor TItratiONFrançois LamontagneChantal Langevin, Janet OverveldeEnrollingLearn More
OSCILLATE — Oscillation for ARDS Treated EarlyMaureen Meade & Niall FergusonLori HandCompletedLearn More
Knowledge transfer and best practices in emergency medicine and in traumatology: impact of wikisPatrick ArchambaultCarrie Anna McGinnEnrollingLearn More
IOStudy — International Observational StudyKaren Burns
Ms. Leena Rizvi, Ms. Kelly KlouvidakisEnrollingLearn More
Improvement of ventilatory support during pediatric non-invasive ventilationGuillaume EmeriaudNicole PoitrasEnrollingLearn More
HICCUPS - Hypovitaminosis-D In Critically ill Children: Understanding Pathways and Solutions (1)Dayre McNallyKatie O’HearnEnrollingLearn More
GRASP1 - Global Resource Allocation Survey ProjectMichael ChristianMelanie GuenetteEnrollingLearn More
FAST TrialKaren Burns

Leena RizviCompletedLearn More
EXERCISE - The EXercise and Early Rehabilitation in Critically Ill Children: a Systematic Evaluation Research ProgramKaren Choong
 EnrollingLearn More
DDePICt - Determination of Death Practices in Intensive Care Resarch ProgramSonny DhananiAmanda van BeinumEnrollingLearn More
CYCLE - Critical Care Cycling to Improve Lower Extremity StrengthMichelle KhoFrance ClarkeEnrollingLearn More
Canada DONATEFrederick D'Aragon, Maureen Meade

Aemal Akhtar, Erika Arseneau, Lori Hand, Marie-Hélène Masse
EnrollingLearn More
BALANCE — Bacteremia Antibiotic Length Actually Needed for Clinical EffectivenessNick Daneman & Rob FowlerA RishuCompletedLearn More
aC3KTion Net — A Canadian Critical Care Knowledge Translation NetworkJohn Muscedere Nicole O'Callaghan & Nomusa MngomaNot Yet Recruiting Learn More
ABLE - Age of Blood Evaluation Study: a Multicenter Randomized Clinical TrialJacques LacroixPaul Hébert, Dean Fergusson and Alan TinmouthLucy ClaytonPublishedLearn More
ABC PICU — Age of Blood in Children PICUMarisa TucciNicole Poitras & Lucy ClaytonEnrollingLearn More