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  • Canadian Critical Care Trials Group
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Programs

Principal Investigator(s)

Coordinator(s)

Lucy Clayton

Status

Enrolling

PIT-TBI

Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Many survivors suffer from concentration deficit, fatigue, depression and low resistance to effort. These symptoms affect their quality of life, their functional level and have a significant impact on primary health care resources utilization. Several of these symptoms could be attributable to hormonal deficits. In fact, pituitary disorders are an often neglected side effect of TBI. Nonetheless, studies published to date have not adequately evaluated the clinical impact of pituitary disorders nor their risk factors in the context of TBI.

The main objectives of this study will be to evaluate the feasibility of conducting a large multicenter prospective observational cohort study. We will evaluate protocol adherence and we will estimate the recruitment rate at each participating centre.

This study, conducted in 5 trauma centres across Canada, is a critical step in an innovative research program on pituitary disorders. This study will have a significant impact on health care in Canada. Indeed, if we demonstrate that pituitary disorders affect the neurological prognostic, functional status, quality of life or depressive symptoms of patients, our results will justify the implementation of a systematic screening strategy to detect these disorders in patients suffering from TBI.

These results would then also justify the conduct of randomized clinical trials to evaluate the relevance of initiating hormonal replacement therapy. On the other hand, if we show that pituitary disorders and prognosis are not linked, our results will prevent unnecessary, costly screening and prevent potentially harmful hormonal replacement therapy in this vulnerable population.

FUNDING:
This study is funded by a grant from the Canadian Institute of health Research and by a grant from the Fonds de la Recherche du Québec - Santé.

Participating Centers

CHU de Québec –Université Laval, Hôpital de l’Enfant-Jésus (Québec City, Québec) ; Hôpital du Sacré-Cœur de Montréal (Montréal, Québec) ; Centre Hospitalier Universitaire de Sherbrooke (Sherbrooke, Québec) ; The Ottawa Hospital (Ottawa, Ontario); Sunnybrook Health Sciences Centre (Toronto, Ontario); Nova Scotia Health Autority (Halifax, Nova Scotia).