• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.

Principal Investigator(s)

Frederick D'Aragon, Maureen Meade


Aemal Akhtar, Erika Arseneau, Lori Hand, Marie-Hélène Masse



View Website



We are launching a research program studying  organ donation practices in Canada. Our five year plan is to develop a sustainable collaboration that is national and international in scope.The DONATE observational study lay the foundation for these plans and includes a 1 year,  approximately 25  centres study that will have immediate relevance to clinical practice and will also pave the way for national clinical trial in Canada. For every participant, we will collect data at different steps of  the organ donation process in ICU and operating room.

Objectives: To lay a strong foundation for national clinical trials in the ICU management of deceased organ donors, fostering collaboration with hospitals, organ procurement organizations and transplant programs.

Design: 12-month, prospective observational study.

Setting:  ~25 organ donation hospitals across Canada.

Population:  consented organ donors (DND, DCD)

Observation:     We will document clinical practices related to donor care, organ assessments, and death declaration (where applicable) through direct observation, chart review, and electronic records.  We will also follow up with transplant recipients.

  1. descriptive analyses
  2. knowledge translation tools: evidence bulletins; site reports
  3. research innovations (i.e., generic outcome measure of graft function)
  4. Quality assurance

Participating Centers

Hamilton, London, Sherbrooke, Montreal (Sacre Cœur), others TBD.