• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.
Programs

Status

Published

The REALISTIC 80 Study

Realities, Expectations and Attitudes to LIfe Support Technologies in Intensive Care for Octogenarians

Seriously ill hospitalized elderly patients rate ‘not being kept alive on prolonged life supports’ as the most important aspect of good quality care at the end of life (EOL). Across Canada, large numbers of elderly patients near the EOL and their families are faced with decisions about whether or not to use mechanical ventilation or other forms of life support technology used in intensive care units (ICUs).  We do not know whether these patients and their families are informed about the realities of intensive care – that is, if they are aware of the likelihood of surviving a critical illness and the resultant health states.  The outcomes of critical illness for this patient population and their families are unknown, despite the crucial importance of this information to guide clinical decision making. The goals of our research program are to understand the realities of critical care, and the expectations and attitudes of patients 80 years of age or older (80+) and their families about the use of life sustaining technology.  Specifically, in this project, we want to determine the realities or outcomes of surviving critical illness.

Our primary research question is:
1)  What are the 12-month health-related quality of life (HRQOL), functional status, and survival of patients admitted to ICU who are 80+ years old?
Our secondary research questions are:
2)  Which patient characteristics are associated with 12-month HRQOL, functional status, and survival?
3)  What is the satisfaction of family members with critical care, as measured by the  Family Satisfaction in ICU (FS-ICU 24) instrument?
4)  For patients surviving their ICU stay, what is the experience of family members caring for
the patient during follow up, as measured by the Caregiver Reaction Assessment (CRA)
instrument?
5)  For patients who do not survive their ICU stay, what is the family satisfaction with EOL care, as measured using the CANHELP Satisfaction (Bereavement) instrument?
6)  What is the health-related financial burden experienced by patients and their caregivers during their initial ICU hospitalization and up to 12 months after the index ICU admission?
7) What is the quality of decision making regarding the goals of care for an 80+ ICU patient?
8) What are the values that influence decisions about the goals of care for this population?

We are conducting a national, multicentre, cohort study of 600 patients age 80+ years who are admitted to Canadian ICUs.  We will follow these patients prospectively for 12 months to measure study outcomes.  In addition, using novel instruments that we have already developed and validated, we will follow family members of these patients to document their experience as caregivers, their satisfaction with care of their relatives, and the financial implications of having a critically ill loved one.  This quantitative project will be complemented by a separate qualitative study in the community setting to further understand the expectations and attitudes of persons over 80 years of age regarding the use of life sustaining technology.  Data emerging from this work will inform important clinical decisions regarding critical care and EOL care for this aged population.

We presume that the short- and long-term mortality of 80+ year olds admitted to Canadian ICUs will be high and that the self-reported health-related quality of life and functional status of survivors after hospital discharge will be low. We anticipate that pre-morbid illnesses and functional status before admission to ICU will correlate with long-term clinical outcomes.  We are uncertain as to the psychological and financial burden experienced by families when a loved one is in the ICU and during the recovery phase; our study will be the first to furnish such important information. By using administrative databases to complement information already being collected in this study, we will obtain a better understanding of the healthcare resource utilization and longer term survival of this cohort, and will be better positioned to offer effective ICU and follow-up care for this at-risk patient population.

Study Progress to Date/ Status
Our study was funded by the Canadian Institutes of Health Research. Recruitment is complete as of February 29, 2012.  Follow-up is continuing until January 31, 2013. We anticipate discussing the preliminary results and developing our program’s next steps in June 2013 at the CCCTG meeting.

Co-Investigators

Peter Dodek, Seen Keenan, Steve Reynolds, Gordon Wood,  Jim Kutsogiannis, Sean Bagshaw, Tom Stelfox, Dan Stollery, John Reid, Allan Garland, John Muscedere, Deborah Cook, Dr. Sangeeta Mehta, Richard Hodder, Rob Fowler, Neil Lazar,  Karen Burns, Stephan Ahern, Martin Albert, Alexis Turgeon-Fournier, Francois Lellouche

Participating Centers

CHU de Québec - Hôpital de l’Enfant-Jésus (Quebec city, Quebec), Hôpital du Sacré-Coeur de Montréal (Montreal, Québec), Hôpital Laval (Quebec, Quebec City),  Hôpital  Masionneuve Rosemount (Montreal, Québec),

The Ottawa Hospital-Civic Campus (Ottawa, Ontario), Sunnybrook Health Sciences Center (Toronto, Ontario), St-Michael's Hospital (Toronto, Ontario), Hamilton Health Sciences Center (Hamilton, Ontario),  Kingston General Hospital (Kingston, Ontario); St. Joseph’s Healthcare (Hamilton, Ontario), Mt. Sinai (Toronto, Ontario), Toronto General Hospital (Toronto, Ontario)

Winnipeg Health Sciences Center (Winnipeg, Manitoba), St. Boniface Hospital (Winnipeg, Manitoba)Royal University Hospital (Saskatoon, Saskatchewan)

Foothills Health Sciences Center (Calgary, Alberta), Royal Alexandra Hospital (Edmonton, Alberta),
University of Alberta Hospital (Edmonton, Alberta), Peter Lougheed Hospital (Calgary, Alberta), Grey Nuns Community Hospital (Edmonton, Alberta)

Victoria General Hospital (Victoria, British Columbia), Royal Jubilee Hospital ( Victoria, British Columbia), Royal Colombian Hospital (New Westminster, British Columbia), Surrey Memorial Hospital (Surrey, BC), St. Paul’s Hospital (Vancouver, British Columbia)